Following the path taken in the Champions League so far, Simone Inzaghi plans to make extensive changes ahead of Tuesday night’s clash with Bayer Leverkusen.

Until now, this strategy has proven more than successful, especially against high-profile opponents like Manchester City, Arsenal, and RB Leipzig. Encouraged by the positive outcomes this season, the coach is expected to change several players from the team that played last Friday in the league against Parma.

In defence, de Vrij and Bisseck will likely be called upon to put in extra work due to the ongoing emergency situation. Instead of Bastoni, Darmian should start in the three-man line in front of Sommer, with Bisseck shifted to the left centre.

In the midfield, according to La Gazzetta dello Sport, both Frattesi and Zielinski are eager to become starters. On the left, Carlos Augusto may give Dimarco a rest, while on the right, Inzaghi could once again deploy Dumfries.

Upfront, the only certainty is Lautaro Martinez who is on the hunt for a goal he’s been relentlessly pursuing. There’s a tight race between Taremi and Arnautovic for a spot alongside him, while Thuram is likely to start from the bench.